Journal article
Risk factors for melanoma by anatomical site: an evaluation of aetiological heterogeneity*
R Laskar, A Ferreiro-Iglesias, DT Bishop, MM Iles, PA Kanetsky, BK Armstrong, MH Law, AM Goldstein, JF Aitken, GG Giles, HA Robbins, AE Cust, GJ Mann, H Schmid, JL Hopper, BK Armstrong, E Holland, RF Kefford, MA Jenkins, JA Newton Bishop Show all
British Journal of Dermatology | WILEY | Published : 2021
DOI: 10.1111/bjd.19705
Abstract
Background: Melanoma aetiology has been proposed to have two pathways, which are determined by naevi and type of sun exposure and related to the anatomical site where melanoma develops. Objectives: We examined associations with melanoma by anatomical site for a comprehensive set of risk factors including pigmentary and naevus phenotypes, ultraviolet radiation exposure and polygenic risk. Methods: We analysed harmonized data from 2617 people with incident first invasive melanoma and 975 healthy controls recruited through two population-based case–control studies in Australia and the UK. Questionnaire data were collected by interview using a single protocol, and pathway-specific polygenic risk..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council of Australia (NHMRC) (project grants 566946, 107359, 211172 and programme grant number 402761); the Cancer Council New South Wales (project grant 77/00, 06/10), the Cancer Council Victoria and the Cancer Council Queensland (project grant 371); the US National Institutes of Health (NIH) [NIH RO1 grant CA83115 to Genomel (www.genomel.org)]; Cancer Research UK (Project Grant C8216/A6129 and programme awards C588/A4994, C588/A10589 and C588/A19167); NHMRC Career Development Fellowship (#1147843) to A.E.C.; and, in part, by the Intramural Research Program of the National Cancer Institute, the NIH and the Division of Cancer Epidemiology and Genetics.